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The other hallmarks leading to further transition to cancer may be acquired later in the evolution of the tumor

Irreversible inhibitor An inhibitor that possesses an off-rate that is slow relative to the rate of re-synthesis of the target protein in vivo , so that once the target protein is inhibited, it does not regain activity

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A feedback loop driven by H4K12 lactylation and HDAC3 in macrophages regulates lactate-induced collagen synthesis in fibroblasts via the TGF- signaling

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