This finding does not establish causality, but it is consistent with a model in which robust mitochondrial peptide signaling is a feature of successful aging rather than a peripheral correlate
The present invention solves these problems by providing BPC peptide salts and a pharmaceutical or diagnostic composition comprising a pharmaceutically or diagnostically effective amount of the salts of BPC peptides said peptides being constituted of 8 to 15 amino acids, wherein the anion of the salt is a negatively charged peptide comprising 8 amino acid residues having the general formula (I) Yaa is a basic amino acid residue, in particular Lys, Arg, Orn or His and Zaa is an acidic amino acid residue, in particular Glu, Asp, Aad or Apm and wherein the cation of the salt is the cation of an inorganic or organic nontoxic and pharmaceutically acceptable base
For example, overexpression of the BRCP/ABCG2 transporter is associated with resistance to several anti-cancer drugs including doxorubicin, mitoxantrone and topotecan [65], whilst ABCB1/MDR1 is frequently overexpressed in drug-resistant cell lines and is found to correlate with poor overall survival in patients [20, 66]
Cat #: BEK-2211-2P, Biosensis Pty Ltd., SA, Australia), ChemKine TM BDNF Sandwich ELISA (Cat #: CYT306) and Milliplex Map Human Pituitary Magnetic Bead Panel 2 - Endocrine Multiplex Assay, based on Luminex /xMAP technology (Cat #: HPTP2MAG-66K, both from EMD Millipore Corporation, Billerica, MA, USA), BDNF Emax Immuno-Assay System (Cat #: G7610, Promega Corporation, Madison, WI, USA), Quantikine human BDNF Immunoassay (Cat #: DBD00, R&D Systems, Inc., Minneapolis, MN, USA)
The residual liquid from tubes was cleared by filtration and lyophilized to obtain crude gastric juice concentrate
