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Nano-cannabidiol to orchestrate inflammatory homeostasis via macrophage metabolism reprogramming for targeted treatment atherosclerosis

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At the core of this redox-sensitive signaling pathway lies the suppression of the pro-inflammatory NF-B pathway and the activation of the cytoprotective Nrf2 pathway

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When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis