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The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM 5-TR) describes OUD as a pattern of opioid use leading to problems or distress, where at least two of the following occurring within a 12-month period: Taking larger amounts or taking drugs over a longer period than intended

Acknowledgements The authors give thanks to J

163 Flavonoids including baicalin, baicalein, phloridzin, and phloretin have been demonstrated to possess inhibitory effects on human erythrocyte GST 164 while Majidinia et al have elucidated the suppressive influence of emodin and quercetin on GSTP1, contributing to the mitigation of chemoresistance in cancer cells