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Description

However, it was recently found that preventing accumulation of ferrostatins in lysosomes by reducing the extent of molecular trapping via the lysosomotropic effect improved the potency of ferroptosis inhibitors, which indicates that lysosomes are not critical for ferroptotic suppression [35]

200 , e45e67 (2019)

In this study, we observed that YTHDF1 binds to m6 A-modified GSTM2 mRNA, and YTHDF1 KO impairs GSTM2 mRNA stability, leading to a decrease in its levels