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In animal studies, doses are typically scaled by body weight at approximately 110 mcg/kg

323,324 The influential role of ALOX12, ALOX15, and 12-HETE on diabetes progression is also correlated with NOX (nicotinamide adenine dinucleotide phosphate oxidase)-mediated endoplasmic reticulum stress, TRPV1 activity, and MAPK signaling, ultimately leading to cell apoptosis