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Tirzepatide at its highest dose (15 mg) produced 22.5% weight loss in the SURMOUNT-1 trial (N=2,539) at 72 weeks [8]

The value is adjunctive: they prevent hepatic fat accumulation during aggressive calorie restriction, and they correct B12 deficiency that would otherwise limit exercise capacity and metabolic rate

Given the theme of the games, it seems reasonable to expect that the legendaries will feature some combination of flying or water types over a type mix we've yet to see