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Moreover, calcium supplementation has been shown to aid in weight loss in obese humans consuming a calorie-deficient diet (142) and in calorie-restricted obese mice (111), and has also been reported to inhibit weight regain during refeeding in mice (122)

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Additionally, rather than relying solely on the mean zeta potential, surface charge heterogeneity should be considered, as subpopulations with distinct charges can markedly influence interactions with biological systems, including circulation, cellular uptake, and tissue distribution (Lee et al., 2011)