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FIGURE 1 3.1.2 Transcriptional regulation of GPX4 by the Nrf2 pathway Nuclear factor erythroid 2-related factor 2(Nrf2), is a master transcriptional regulator of the cellular response to oxidative stress

6,7FDA warns against the use of injectable glutathione as a skin whitener because whitening is not an approved use,9 efficacy is not well-established, and there have been reported side effects(acute renal failure, severe drug reactions such as generalized morbilliform eruption with angioedema and urticaria, vasculitis, anaphylactic shock and many documented side effects based on studies on IV glutathione used as skin whitening).6,7,8, 12

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Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury