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F.ReymondL.GibelinA.AbramiL.DecoutA.et al (2018)

The first reaction is catalyzed by tryptophan hydroxylase (TPH-1), which requires L-tryptophan, tetrahydrobiopterin (BH4), and O 2 as co-substrates, and has ferrous ion (Fe 2+ ) as an activator

Sterne JA, et al

Clinical translation of ferroptosis modulators also faces significant bottlenecks, including bioavailability, limited tissue specificity, and potential toxicity or off-target [134, 135]

New Phytol 209:10281039 Xu D, Wu D, Li XH, Jiang Y, Tian T, Chen Q, Ma L, Wang H, Deng XW, Li G (2020) Light and Abscisic acid coordinately regulate greening of seedlings