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The dense connectivity visualized in Figure 2F emphasizes the interplay between various signaling pathways and molecular mechanisms underlying AD

Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy

Non-human primates (NHPs), such as rhesus monkeys, naturally exhibit age related tau and amyloid (A) pathologies, providing models that closely mimic human disease progression (Li et al., 2019)