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Following a dose regimen of 100 mg four times a day for 7 days, average urinary drug recoveries (0 hour to 24 hours) on Day 1 and Day 7 were 42.7% and 43.6%

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In experimental models, transcriptomics identified two main gene clusters associated with microglia, these being a homeostatic cluster given the term M0, defined by P2ry12, Tmem119, Cx3Cr1 , and an inflammatory cluster termed MGnD defined by Ccl2, Csf1 , and Apoe

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Neurology 64, 442447