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To further confirm the direct role of XKR8 in NET formation in vivo, we generated neutrophil-specific Xkr8 KO mice by crossing Xkr8 floxed mice ( Xkr8 fl/fl as the controls) with Ly6g cre KI mice, resulting in neutrophil-specific XKR8 KO mice ( Xkr8 fl/fl Ly6g cre ) (Extended Data Fig

2018), and because it is expressed in the area postrema of the medulla, along gastric enteric and vagal nerves, and on cutaneous receptors in the dermis and epidermis (Tissue expression of TRPV1 - Summary - The Human Protein Atlas n.d), researchers postulate that repetitive TRPV1 activation may cause vomiting from overexcitation, or relief from the vomiting under acute activation of the hot shower

Integrative analysis of ferroptosis-related genes in ulcerative colitis

Medler, 2015)

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