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Peer-reviewed studies on Epithalon Khavinson VKh, Bondarev IE, Butyugov AA (2003)

The melting point is sensitive to extremely large changes in pressure, but generally this sensitivity is orders of magnitude less than that for the boiling point, because the solid-liquid transition represents only a small change in volume

This can create a paradoxical effect, where the individual feels less drunk due to the stimulating effects of caffeine but is actually more impaired

(2005) A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer

The updated prescribing information can be found here