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doi: 10.1093/molehr/gan033 17

their off-target effects and reversibility require further clarification

doi: 10.1007/s11032-021-01215-2 52 LiuC.ZhangY.TanY.ZhaoT.XuX.YangH.et al

However, the transporters, such as OCTN2, GLUTs, LAT1 and SVCT2 (Table II, III), used for brain delivery of mentioned therapeutic agents, are expressed at both the BBB and brain parenchymal cells, and, therefore, can be more suitable for the brain delivery of the drugs with intracellular targets

So, there is a need to explore, identify and understand the factors that may influence the effect of PROTACs, and thus find strategies to optimize their impact