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This is a classic sign in Hashimotos autoimmune pathophysiology (22)

Koneru et al

We demonstrated that the GSH synthesis inhibitor buthionine sulfoximine (BSO) synergistically enhanced L-PAM activity (inducing 24 logs of cell kill) against nine MM cell lines (also in the presence of marrow stroma or cytokines) and in seven primary MM samples (combination indices 100 days, and significantly increased the median event-free survival relative to L-PAM alone

Metformin in women with type 2 diabetes in pregnancy (mity): a multicentre, international, randomised, placebo-controlled trial

Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice