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Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamine

Biochem J (1984) 221(2):4715

Establishment of cisplatin-induced AKI mouse model Idh1 WT/WT Ksp Cre mice and IDH1-R132H mutant ( Idh1 WT/Mut )Ksp Cre mice were housed in a pathogen-free environment and randomly divided into the following groups ( n = 6 per group): control group, cisplatin group, cisplatin + Liproxstatin-1 (Lip-1) group, and cisplatin + benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD) group

The injectate should proceed without any resistive pressure and often an expansion of fluid can be seen anterolaterally consistent with inflation of the bursa

Many redox couples in a cell (e.g., oxidized/reduced NAD(P), TRx, GRx) work together to provide electron transfer in order to maintain the cellular redox state