does glutathione reductase have iron Frontiers Glutathione and the Cofactors

revealed that GPX4 overexpression prevents basophilic leukemia cells in mice from death caused by oxidative damage (Imai et al., 1996), thus, theoretically, GPX4 overexpression could make cells resistant to oxidative stress-induced ferroptosis

However, GSK-3/, a central regulator in lung SCC cells, can promote the expression of GLS and glutamine metabolism by upregulating c-MYC and c-JUN to make cancer cells adapt to chronic mTOR and glycolysis inhibition (85)

J Organ Dysfunct

Pan C, Ji Z, Wang Q, Zhang Z, Wang Z, Li C, et al

In the treatment of CAG by XJZ, principal drug was the most important, and assistant drug and complement drug could assist the principal drug