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Mechanistic studies further confirm that SCFAs enhance intestinal barrier function ( Zinc intestinal barrier anti-inflammatory pathway: human RCTs (252) demonstrate that zinc supplementation (20 mg/day) upregulates the expression of intestinal tight junction proteins (e.g., occludin) and reduces systemic inflammation

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Free Radic Biol Med 152:227234 Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease