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However, it is imperative to note that findings from animal models cannot be directly extrapolated to clinical trials in humans

[3] The same work profiled shifts in the cecal microbiome associated with treatment

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The absorption process is significantly hindered in conditions such as pernicious anemia, Crohns disease, celiac disease, and following ileal surgical resection, all of which can impair B12 absorption and contribute to suboptimal supplementation outcomes