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A systematic review of the impact of vincristine plus steroid pulses from more recent clinical trials raised the question of whether such pulses are of value in current ALL treatment, which includes more intensive early therapy and risk stratification incorporating early response (MRD) and biological factors.[121] In a multicenter randomized trial in children with intermediate-risk ALL being treated on a BFM regimen, there was no benefit associated with the addition of six pulses of vincristine/dexamethasone during the continuation phase, although the pulses were administered less frequently than in other trials in which a benefit had been demonstrated.[122] A small multicenter trial of average-risk patients demonstrated superior EFS in patients receiving vincristine plus corticosteroid pulses

Not every trial agrees, either

Dattatray Shinde, S

Also, combining cytokine-manipulating nanoparticles with established therapies, including immune checkpoint inhibitors and chimeric antigen receptor T cell therapy, may improve therapeutic outcomes (216218)

Qige Decoction inhibits hepatic steatosis by reducing hepatic insulin resistance and triglyceride biosynthesis via the PPP1R3C/SIK1 signaling axis [153]