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Apart from ROS being created as a result of oxidative glucose metabolism, the constant exposure of retinal cells to sunlight and artificial light triggers the production of ROS 16,17 , especially with photosensitizers present, such as retinoids 16,18 , and leads to photo-oxidation 19

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By triggering pyroptosis and promoting the production of pro-inflammatory proteins, the NLRP3 inflammasome aids in fibrogenic processes

105 Moreover, PRDX1 inhibits cumene hydroperoxide-induced ferroptosis in corneal endothelial cells

doi: 10.1016/j.cub.2014.01.013 Schroeder, Christina I., Rash, Lachlan D., Vila-Farrs, Xavier, Rosengren, K