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Key Takeaways TEV is highly specific but not infinitely specific : cryptic ENLYFQ-like motifs in your sequence can be cleaved, especially in disordered or exposed loops PreScission/3C protease tolerates more variation at P1' than its consensus suggests , particularly Gly/Ala/Ser/Met in the P1' position Accessibility matters more than sequence purity : a perfect site buried in the core won't cut

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Epidemiological evidence from Zaire for a dietary etiology of konzo, an upper motor neuron disease

Management: regular CBC monitoring, dose adjustment, hydration, blood donation if needed

Nervous System Research Understanding neurological health remains a major scientific objective