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Human mutation data reported

Here, we systemically demonstrate that GDIL drives acquired platinum resistance by inhibiting GSH degradation instead of increasing GSH synthesis, through GDIL/XRN2/CHAC1 pathways

In addition, proliferation of breast cancer is enhanced by insulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF), which stimulate signaling through the MAPK and PI3K/AKT pathways by activation of IGF-1R and EGFR receptors, respectively

However, their specificity for ferroptosis versus generalized oxidative injury remains a key uncertainty

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