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Stud Nat Prod Chem 65:239269 Brewer M (2011) Natural antioxidants: sources, compounds, mechanisms of action, and potential applications

Tet1 and Tet2 mainly regulates the level of 5-hydroxymethylcytosine (5hmC) in the promoter region of primordial germ cell (PGCs) genes or 5hmC inside PGCs gene, while Tet3-mediates paternal active DNA demethylation [7, 64, 65, 89, 94, 134, 161]

Individuals with variants in ABCB11 rarely develop cholestasis until BSEP function drops below a threshold, which is also influenced by other factors (e.g., drugs, hormones)