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In particular, metformin exerts its anti-inflammatory effects by engaging the AMPK/ATF3 signaling axis, through which it potently manages inflammation associated with type 2 diabetes and obesity (187)

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Many trials recruited younger participants outside our target demographic of 3065 years, limiting the available evidence for middle-aged and older adults

A weakly informative prior for between-trial heterogeneity ( ), specifically an HN prior with a scale of 0.5, was applied 29 , whereas uninformative priors were used for treatment and interaction effects