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Wu, Escape from Therapy-Induced Accelerated Cellular Senescence in p53-Null Lung Cancer cells and in human lung cancers

(2021) 131(4):76075.e7

Therapeutic efforts should move beyond broad-spectrum agents toward highly specific modulators, including structure-guided inhibitors of core regulators such as GPX4, emerging modalities such as PROTAC-based approaches to selectively degrade pro-ferroptotic proteins, and targeted nanomedicine systems for site-specific delivery

Social situations are one of the most powerful craving triggers because they combine environmental cues, peer behaviour, and reduced inhibition

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