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10.1016/s0041-008x(03)00240-0 28 Elsayed ElgarawanyG.AbdouA

Hyperpigmentation refers to the darkening of certain areas of the skin

Depletion of cystine/cysteine reduces intracellular GSH levels and GPX4 activity within the cystine/cysteine-GSH-GPX4 axis, thus causing ferroptosis (18,99)