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Correcting B12 changes your metabolism and nervous-system signalling, and that adjustment itself can feel like tiredness, lightheadedness or a vague off feeling before things settle

All patients obtained informed consent

We document baseline standardised photography under controlled lighting so we can measure change objectively rather than relying on memory

All combination data comes from anecdotal clinical observations or theoretical synergy based on separate mechanisms

Pharmaceutical preparation: Each 30 mL vial contains: 100 mg of vitamin B1 in form of thiamine hydrochloride, 2 mg of vitamin B2 in form riboflavin-5-Phosphate Sodium, 100 mg of B3 in form niacinamide, 2 mg of vitamin B5 in form of dexpanthenol and 2 mg of vitamin B6 in form of pyridoxine hydrochloride