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In response to these stimuli, microglia express proinflammatory cytokines such as TNF-, IL-1, IL-16 and chemokines such as monocyte chemoattractant protein-1 (MCP-1) or IL-18, which are responsible for cell recruitment and removal of pathogenic substances ( Proinflammatory mediators released by neuroinflammatory M1 microglia, such as C1q, IL-1, IL-1, or TNF-, have the ability to induce activation of the A1 astrocyte phenotype, which will be responsible for a secondary inflammatory response (Saijo et al., 2009

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Popat U, Saliba R, Thandi R, Hosing C, Qazilbash M, Anderlini P, Shpall E, McMannis J, Krbling M, Alousi A, Andersson B, Nieto Y, Kebriaei P, Khouri I, de Lima M, Weber D, Thomas S, Wang M , Jones R, Champlin R, Giralt S