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Description

Antioxidants 13:541

Glycosides Forsythoside A (FA), a principal bioactive constituent derived from Forsythia suspensa , exhibits a range of pharmacological properties including anti-inflammatory, antimicrobial, antioxidative, and neuroprotective activities

The cytotoxic effect of TMZ is primarily exerted by methylation of O 6 position of guanine ( O 6 -meG) which escapes O 6 -meG-DNA-methyl transferase (MGMT) repair resulting in futile cycles of mismatch repair leading to DSBs and triggering cell cycle arrest and apoptosis 32