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In agreement with published data, these cells were hardly sensitive to FA when compared to the isogenic cell line expressing a wild type copy of FANCD2 (PD20-wtD2) 39 (Fig

They reported on a small subpopulation that survived lethal exposures and then reseeded growth in exposed biofilms (LaFleur et al., 2006)

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Pathological immobilisation of iron by protein aggregates such as amyloid and tau may sequester iron in a non-bioavailable form, or impaired autophagy may prevent efficient breakdown of ferritin to mobilise iron, thereby impairing mitochondrial ATP production and subsequently glutathione synthesis, an essential component of the ferroptosis defence system [29]