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E.PreussM

The loss of MMP, elevated ROS, and ccf-mtDNA in the BD COs made them more prone to NLRP3 activation, which, in turn, further increases ccf-mtDNA therefore, causing the CO homeostasis to be disrupted both intracellularly and extracellularly

10.1038/s41586-020-03116-4 Nature 168 SchaferK

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