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The investigators reported that LR3-IGF-1 produced greater anabolic effects than native IGF-1 across both administration modes, with the differential most pronounced under once-daily injection conditions

Consequently, the further inhibition of Gln metabolism and fatty acid metabolism through the suppression of ASCT2 expression, which poses a significant threat to the energy supply required for cancer cell proliferation, emerges as a promising anticancer target

For GSDME overexpression in mice liver, 1 10 9 PFU of adenovirus was injected into Gsdme -/- mice via tail vein and mice were used for experiments after 5 days of maintaining under controlled conditions

10.3389/fonc.2024.1334915 147