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Gustafson C, Koslosky M, Leslie J, Walczak C

Heterologous expression of an engineered bifunctional bacterial GSH biosynthetic enzyme (GshF) in mitochondria enables mitochondrial GSH production and ameliorates the metabolic and proliferative defects caused by its depletion

First, NK cells can kill glioma cells by secreting perforin and granzyme B upon induction by IFN- (227)

The Secretary may: Direct agency priorities Encourage enforcement discretion Appoint or replace FDA leadership Order internal review of regulatory positions Support re-evaluation of prior safety determinations The Secretary may not: Bypass statutory requirements Ignore the Administrative Procedure Act Unilaterally legalize peptide compounding Regulatory change must follow defined legal pathways

(2018) 48:10141028.e6