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It can be specifically internalized by M1 cells, release ART and DEX, scavenge ROS, inhibit the HIF-1/NF-B pathway, and mediate repolarization of macrophages

Proceedings of the National Academy of Sciences 103 (44): 1626016265

In fact, they compete for the same coregulators, such as PGC1 and GRIP-1, and genes also compete for shared local enhancers, so that the activation of one gene may repress another that relies on the same enhancers (83)

Several research teams have targeted GSH synthesis inhibitors as potential therapeutic agents

Randomised, controlled, doubleblind study of combination therapy of oral tranexamic acid and topical hydroquinone in the treatment of melasma