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Studies (42, 43) have shown that apigenin has a pro-apoptotic effect in human RA-FLS, and it can induce RA-FLS apoptosis by mediating ROS and oxidative stress activator ERK1/2, and mediate apoptotic cell death by activating the apoptotic effector caspase-3/7

Thus, the development of depression will not only seriously impair the quality of life of GD patients but also aggravate the original condition of GD and affect its prognosis

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Common and Rare Adverse Effects Injection site reactions represent the most common side effects, including redness and swelling (mild, transient), bruising, mild burning or cramping reported by some users, and local irritation typically resolving within hours to days

Guerrero, Sergio A