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Selection of candidate mutants for functional validation Candidate variants were further screened for their prevalence in the TCGA patient population

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Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

GSH being regarded as the main cellular antioxidant that acts as determining factor of the cellular redox state by regulating various redox signaling by reacting with ROS that is produced in response to various stresses thereby acting as a major scavenger 50,51