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Controversially to the evidence that CBS is linked to carcinogenesis, a study presents CBS as a tumor suppressor gene, claiming that in gastric and colorectal cancer the expression of CBS is inhibited by DNA methylation in association with KRAS mutations (88)

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It is plausible as a result that the equivocal findings in respect of CM ingestion and exercise performance could also be partly attributed to the amount of ingested citrulline being lower than intended