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Statements Author contributions EE: Writing original draft, Conceptualization, Project administration, Writing review & editing

Where fear is usually to keep us safe, for example, if we look over a cliff, it keeps us from walking right off the cliff

Garca-Dez, E

This strong conservation of kinase specificity across the animal kingdom probably reflects the necessity of preserving specific roles for kinases and substrate sequences that cannot be independently evolved while maintaining organismal fitness 57