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By applying mathematical equations to our experimental data, we demonstrate that the permeability of H 2 O 2 allows an extracellular-to-intracellular peroxide gradient of around 40-fold at sub-toxic levels (100200 M), but peroxide scavenging, mainly driven by Tpx1 at low doses of peroxides and initial time points, generates transient gradients of 300-fold

Tari, AM, Neamati N, Andreeff M , Lopez-Berestein G

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"Alternative respiratory pathways of Escherichia coli : energetics and transcriptional regulation in response to electron acceptors"

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