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Regional prevalence rates are currently highest in the Middle East (32%) and South America (30%) and lowest in Africa (13%), but prevalence rates are even higher in specific subpopulations such as severely obese (90%) and patients with type 2 diabetes (76%) [1]

Although their importance for protection is indisputable, the concern about ADE of disease arises from the possibility that antibodies present at the time of infection may increase the severity of an illness

Numerous investigations showed that a variety of mechanisms, such as mutations in carbapenemases, increased carbapenemase expression, mutations leading to changes in PBPs expression or function, heightened efflux activity, and reduced membrane permeability could also potentially play a role in the development of resistance to IMI-REL ( 5.3 Plasmid-mediated AmpC- -lactamase In E

Furthermore, patients with LRRK2 gene mutations have reduced activity of complex I in vivo [102], and Lrrk2 in mice protects complex I from inhibitors such as MPP + [101]

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