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Pyroptosis cell death involves inflammasome activation that yields cytokine release, cell injury, inflammatory cell dysfunction, and neurovascular injury with cognitive loss

Pathology and IHC All CRCs undergo IHC for MMR proteins MLH1, MSH2, MSH6, and PMS2 and/or MSI testing [45]

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As a result, maintaining brain iron homeostasis through iron chelation therapy has emerged as a promising strategy to attenuate oxidative stress, inhibit ferroptosis, and modulate disease progression, particularly in neurodegenerative disorders where iron accumulation is well documented (Zheng and Monnot, 2012

The upregulated tryptophan metabolism pathway is also observed in patients with psoriasis, while the role of microbes in the pathway remains to be explored (Harden et al., 2016)