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The majority of NTHi iron requirement is fulfilled by acquisition of haem therefore compounds that restrict haem-assimilation may have higher therapeutic value than those solely targeting iron acquisition

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After the specification and formation of the sclerotome, it undergoes organization and resegmentation where the cells at the caudal boundary of the von Ebners fissure, the furrow that divides the rostral and caudal halves of the somite, will develop into the AF or the vertebral body through condensation of the cells (Christ and Wilting, 1992