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The most frequent TEAEs were injection site erythema, nausea, vomiting and decreased appetite

The cell lysate was clarified by centrifugation at 17,000 x g, at 4 C for 12 min, and the supernatant was transferred to a clean, pre-chilled low-binding Eppendorf tube

It increases the expression of inflammation-related molecules and induces the release of other cytokines [45]

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A negative feedback transcription cycle is eventually formed to maintain the oscillation of the gene expression ( REV-ERB , retinoic acid-borne orphaned binders a ( ROR ), DEC1 , DEC2 , and albumin D-binding ( DBP ), which form an auxiliary loop that stabilizes the main regulatory loop (Ripperger and Schibler, 2006