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Mitochondria-generated ROS regulate autophagy by the direct regulation of Atg4 (autophagy-related gene 4) activity [46,47]

Chen JJ, Yu BPAL

As a cofactor for enzymes such as Mn superoxide dismutase (MnSOD), arginase, and pyruvate carboxylase, Mn contributes to antioxidant defense, amino acid catabolism, and carbohydrate metabolism (Smith et al., 2010)