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The main signaling pathways downstream of the IGF-1 receptor are Ras/MAPK and PI3K/Akt, while these two pathways are responsible for the glucose and lipid metabolism in the liver ( Crosstalk Between Circadian Clock System and GH/IGF-1 Axis Regulatory Effect of the GH/IGF-1 Axis on the Circadian Clock System There are very few reports to identify the regulatory effect of the GH/IGF-1 axis on the circadian clock system

The evidence ladder Here is where the article either earns your trust or loses it

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Endocrinology and metabolism , 291 (6), E1290E1294

Effect of Selenium and Vitamin E on the Level of Sperm HSPA2+, Intracellular Superoxide Anion and Chromatin Integrity in Idiopathic Asthenoteratozoospermia: A Double-Blind, Randomized, Placebo- Controlled Trial