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Combination therapies that modestly lower ferroptosis thresholdsrather than forcibly collapsing antioxidant capacitymay provide a practical route to achieve efficacy with tolerable toxicity

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One possible route of this accumulated astrocytic iron is the extracellular space via FPN, where astrocyte-derived iron can be used by OPCs and microglia in the process of remyelination (65)

Reference: PGL Glutathione is a powerful antioxidant naturally present in the body