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Glutathione redox imbalance in brain disorders

Joint injections can sound intimidating at first

In RPE of AMD patients, the expression of circSPECC1 is downregulated, and circSPECC1 insufficiency leads to oxidative stress-induced ferroptosis, depolarization, and irregular lipid metabolism via circSPECC1/miR-145-5p/CDKN1A axis, and then induces visual impairments and RPE anomalies and interrupts retinal homeostasis (Chen X