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10.1016/j.jaci.2007.09.043 17 Noval RivasM.ChatilaT

At toxic doses, most of the drug is metabolized via the CYP2E1 pathway, resulting in the formation of toxic concentrations of NAPQI

TLRs, present on both DCs and macrophages, mediate immune responses by recognizing PAMPs, such as oxidized LDL cholesterol, lipoproteins, and other endogenous ligands released during stress or inflammation